Webinar course Regeneration VS rejection of tissue in implantology and periodontology.

- The biological events that take place during wound healing

- New regenerative biomaterials for bone and/or periodontal regeneration

- The regenerative properties of Emdogain and an introduction to Osteogain

- Use of Hyaluronic Acid for soft tissue wound healing

- Use of Tetranite as a novel bone adhesive

New and innovative biomaterials are being discovered or created in laboratories at an unprecedented rate, but many of them remain entirely foreign to practicing clinicians. This first lecture addresses this gap in knowledge by summarizing some of the groundbreaking research performed to date on this topic and providing case examples of these biomaterials at work. The lecture begins with a review of the biologic background and applications of bone grafting materials utilized in dentistry. Many next-generation materials and growth factors that will optimize future bone and periodontal regeneration are presented.

- The biological background and scientific rationale for why platelet concentrates speed wound healing

- The advanced made in PRF from low speed centrifugation concept (LSCC) towards horizontal centrifugation

- The critical importance of tubes and the drastic negative impact of incorporating silica/silicone into PRF tubes

- The use of PRF for facial esthetics

- Key areas into future uses of PRF for everyday dental practice

The use of platelet concentrates has had a long-history of use in various fields of medicine as an autologous source of growth factors fabricated utilizing centrifugation of blood under various conditions. While platelet rich plasma (PRP) was proposed as a first-generation platelet concentrate over 3 decades ago, over the past 10 years, platelet rich fibrin (PRF) has seen a steady increase in utilization for a variety of medical procedures due to its lack of anti-coagulation factors favoring fibrin clot formation and faster wound healing. More recently, further research has demonstrated that shorter and slower centrifugation spin cycles (the low speed concept) additionally favors wound healing by incorporating higher populations of white blood cells and progenitor cells within the PRF fibrin matrix leading to higher growth factor release within the local micro-environment. Parallel to these findings, the development of a liquid PRF provides a new formulation of liquid PRF without using anti-coagulation factors that may specifically be combined with currently available bone biomaterials favoring particle stability, angiogenesis and tissue integration. This course aims to highlight the recent advancements made with respect to the newest formulations of platelet concentrates and systematically presents when, where and why specific platelet concentrates may be utilized to further speed wound healing and tissue regeneration for various clinical indications faced in routine daily dental practice.

- The importance of immune cells during tissue integration and homeostasis

- Various vitamin deficiencies and anti-oxidants critical for wound healing and implant integration

- Guidelines for clinicians to present to their patients

- Future research opportunities in the field

Dental implants are generally considered a safe and highly predictable surgical procedure performed by many dental surgeons with the aim of replacing missing teeth. Yet to this day, a number of implants are lost every year for yet explained reasons. Dental implants remain one of the only transmucosal implant utilized in medicine; meaning they integrate directly into bone (a phenomenon called osseointegration) yet span into the oral cavity through transmucosal tissues. In this area, a number of bacteria co-exist with host living cells (primarily epithelial and immune cells) creating peri-implant pockets. Here an array of cytokines and highly active complex compounds are secreted and may reduce host defense/antibacterial properties. This lecture will focus on the importance and relevance of tissue homeostasis as it relates to oxidative stress. Furthermore, one of the most prominent vitamin deficiencies known to mankind, that of vitamin D, is discussed as a primary cause linked with early dental implant failure. Recommended doses and guidelines will be provided for patients with ongoing research presented as it relates to 6 week pre-surgical supplementation program aimed at reducing early implant failure.